ASDA Watford Supercentre was used for three separate scenes in Series 2 of Little Britain. Firstly, for the scene involving Vicky Pollard, the teenage delinquent played by Matt Lucas, who is caught stealing pick-n-mix by the store's security guard and reacts with indignant outrage when accused of doing so. Secondly, a sketch with wheelchair-bound Andy and his selfless carer Lou. With Lou distracted, trying to diplomatically arrange for a car to be moved that's blocking him in, Andy springs out his wheelchair and proceeds to lift the car out of the way before Lou sees him. Lastly, stage hypnotist Kenny Criag, played by Matt Lucas, crashes into a car when reversing and is spotted by onlookers who he then attempts to hypnotise them to remember not what they have just witnessed.

A private mansion near Hemel Hempstead in Hertfordshire becomes Hill Grange Health Spa where Bubbles Devere is on a permanent holiday having no yet settled her bill despite having stayed for four months already. The unfortunate spa manager, Mr Hutton, is constantly avoiding Bubble's advances who is trying to divert his attention away from her ever-increasing account.

Hollywood Bowl in Watford is used for two scenes in the second series. Firstly, a scene where Anne and Dr Lawrence go bowling. Anne is a patient at a psychiatric hospital and Dr Lawrence who is forging ahead with his programme to assimilate Anne into the community. Secondly, Andy and Lou go bowling. As usual, with Lou distracted, Andy jumps out of his wheelchair and gets a strike.

A private country house in Little Berkhamsted in Hertfordshire becomes the home of Harvey's Mother and Father, Mr and Mrs Pincher. The country house is first seen when Harvey brings his new love, Jane, to meet his parents. However, despite being a grown man, Harvey still wants breast-feeding from his mother. The private country house is seen later in series 2 as the house of lady whom is having building work done to her house. She brings biscuits out for the workmen whilst they are on their tea break and expects them to behave like her dogs and fetch the biscuits that she has thrown onto the lawn.

Odyssea Bridal and Evening Wear in Potters Bar sees the failed transvestites Emily and Florence shopping for wedding and bridesmaid dresses.